Rat Kynurenine 3-monooxygenase, KMO ELISA Kit, 96T Protein Post-translational Modification and osteoclasts

and osteoclasts

Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity)

This enzyme catalyzes the reaction which converts mannose-1-phosphate and GTP to GDP-mannose which is involved in the production of N-linked oligosaccharides

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This gene encodes a protein containing a nuclear localization signal and an S-adenosyl-L-methionine binding motif typical of methyltransferases| suggesting that the encoded protein may act on DNA methylation

Rat Kynurenine 3-monooxygenase, KMO ELISA Kit, 96T Protein Post-translational Modification and osteoclastsCatalyzes the hydroxylation of L kynurenine (L Kyn) to form 3 hydroxy L kynurenine (L 3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal