Repac Polyclonal Antibody, 100ul Pipette Controller Isocitrate dehydrogenase [NAD] subunit alpha

Isocitrate dehydrogenase [NAD] subunit alpha mitochondrial encoded by IDH3A is the alpha subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase

and it is required for the association of centromere-associated protein E with the kinetochore

The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members

and it prevents the assembly of the C3 and C5 convertase enzymes

and it is able to suppress apoptosis induced by various signals

Repac Polyclonal Antibody, 100ul Pipette Controller Isocitrate dehydrogenase [NAD] subunit alphaMembers of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP GDP regulated switches that cycle between inactive GDP and active GTP bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5 (Rap guanine nucleotide exchange factor 5), serve as RAS activators by promoting acquisition of GTP to maintain the active GTP bound state and are the key link between cell surface receptors and RAS activation.