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The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome

Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor

Mutations in this gene are a cause of Kostmann syndrome

The gene encoding PRPF38A maps to human chromosome 1

TGFA1 Polyclonal Antibody, 100ul Insect Expression Take your work to theThis gene encodes a protein that binds to transforming growth factor beta (TGF beta) receptors and plays a role in TGF beta signaling. The encoded protein acts as a chaprone in signaling downstream of TGF beta. It is involved in signal dependent association with SMAD4. The protein is also a component of mammalian CORVET, a multisubunit tethering protein complex that is involved in fusion of early endosomes.