PURA Polyclonal Antibody, 100ul Plasmid Preparation Mutations in KRT17 lead to

Mutations in KRT17 lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex

This proto-oncogene may play a role in the regulation of embryonic development and cell growth

This gene is thought to be involved in apoptosis

The encoded preproprotein is proteolytically processed to generate the mature receptor

This protein may also be involved in regulating activation of the peroxisome proliferator-activated receptor

PURA Polyclonal Antibody, 100ul Plasmid Preparation Mutations in KRT17 lead toThis gene product is a sequence specific, single stranded DNA binding protein. It binds preferentially to the single strand of the purine rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute