Rb Polyclonal Antibody, 100ul[BT-AP07687] Recombinant Ab Production The complex is also found

The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells

Alternative splicing of this gene results in two transcript variants encoding two different isoforms| one membrane-bound and one soluble

and mutations in the gene are the cause of 17beta-hydroxysteroid dehydrogenase type 10 (HSD10) deficiency

Transcriptional suppressor

which is essential for the catalytic activity

Rb Polyclonal Antibody, 100ul[BT-AP07687] Recombinant Ab Production The complex is also foundThe protein encoded by RB1 (RB transcriptional corepressor 1) is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in RB1 are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.