Rat Acetyl-CoA Acetyltransferase, Cytosolic, ACAT2 ELISA Kit, 96T Molecular Sciences Mediator is recruited to promoters

Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors

Upon binding| this complex translocates to the cytoplasm| where it interacts with TGF-beta receptor type-1 (TGFBR1)| leading to the degradation of both the encoded protein and TGFBR1

Catalytic activity:Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates

also known as Osler-Rendu-Weber syndrome 1

Dimerization with other BHLH proteins is required for efficient DNA binding

Rat Acetyl-CoA Acetyltransferase, Cytosolic, ACAT2 ELISA Kit, 96T Molecular Sciences Mediator is recruited to promoters