SPRE3 Rabbit Polyclonal Antibody, 20ul Monoclonal Antibodies This protein and the closely

This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability

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The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells

and it initiates membrane penetration of the complex

Mutations in this gene lead to tuberous sclerosis complex

SPRE3 Rabbit Polyclonal Antibody, 20ul Monoclonal Antibodies This protein and the closelyThis gene encodes a protein with a C terminal Sprouty like cysteine rich domain (SRY) and an N terminal Ena Vasodilator stimulated phosphoprotein (VASP) homology 1 (EVH 1) domain. The encoded protein is a member of a family of proteins that negatively regulates mitogen activated protein (MAP) kinase signaling particularly during organogenesis. Alternative splicing results in multiple transcript variants.