GRK 2(Phospho Ser685) Polyclonal Antibody, 50ul Recombinant Protein in a potential gene cluster

in a potential gene cluster at 12q13

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This encoded protein is one of two V1 domain A subunit isoforms and is found in all

The protein is a cancer-associated antigen that can stimulate autologous T-cell responses| and it is therefore considered to be a potential immunotherapeutic target for the treatment of various hematopoietic malignancies| including diffuse large B-cell lymphoma

GRK 2(Phospho Ser685) Polyclonal Antibody, 50ul Recombinant Protein in a potential gene clusterThe product of this gene phosphorylates the beta 2 adrenergic receptor and appears to mediate agonist specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta adrenergic and related G protein coupled receptors. Abnormal coupling of beta adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.