Rat Urocortin, UCN LISA KIT, 96T Site-directed Mutagenesis Multiple alternative transcript variants have

Multiple alternative transcript variants have been described for this gene

it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer

and has been shown to form dimers/oligomers through its leucine-zipper motif

CBL and other signaling intermediates

This gene product shares 98% amino acid sequence identity with the mouse ortholog

Rat Urocortin, UCN LISA KIT, 96T Site-directed Mutagenesis Multiple alternative transcript variants haveActs in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH) (PubMed: 7477349). Binds with high affinity to CRF receptor types 1, 2 alpha, and 2 beta (By similarity). Plays a role in the establishment of normal hearing thresholds (By similarity). Reduces food intake and regulates ghrelin levels in gastric body and plasma (PubMed: 21540451).