SEM6D Polyclonal Antibody, 50ul Protein Post-translational Modification Constitutive activation of this gene

Constitutive activation of this gene caused either by somatic mutations| or genomic duplications of regions that include this gene| have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome

type 1 and type 2

The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells

Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells

tissue specificity:Expression largely restricted to adipose tissue and spleen

SEM6D Polyclonal Antibody, 50ul Protein Post-translational Modification Constitutive activation of this geneSemaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N terminal extracellular portion. Additional sequence motifs C terminal to the semaphorin domain allow