Chicken Sorbitol Dehydrogenase, SDH ELISA Kit, 96T Apoptosis & Autophagy The encoded protein is a

The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides

Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin| a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth

Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway

and is therefore a potential tumor suppressor

Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol phosphatase with the ability to dephosphorylate phosphatidylinositol 3-phosphate and phosphatidylinositol 4

Chicken Sorbitol Dehydrogenase, SDH ELISA Kit, 96T Apoptosis & Autophagy The encoded protein is a