CENPP Polyclonal Antibody, 20ul Human Genome Knockout Libraries Defects in protein kinase C

Defects in protein kinase C gamma have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14)

Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits| large and small| that dimerize to form the active enzyme

4 leucine-rich repeats (LRRs)

There are many pseudogenes of this locus in the human genome

This gene is located on chromosome 1 in a tandem cluster of closely related family members including argonaute 4 and eukaryotic translation initiation factor 2C| 1

CENPP Polyclonal Antibody, 20ul Human Genome Knockout Libraries Defects in protein kinase CCENPP is a subunit of a CENPH (MIM 605607) CENPI (MIM 300065) associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006