Six3/6 Polyclonal Antibody, 50ul Long RNA Synthesis Alterations in the encoded protein

Alterations in the encoded protein may be associated with susceptibility to autism spectrum disorder

Three transcript variants encoding two different proteins have been found for this gene

in addition to the ETS DNA-binding domain in the C-terminal region

II and III

This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins

Six3/6 Polyclonal Antibody, 50ul Long RNA Synthesis Alterations in the encoded proteinHomeobox protein SIX6 encoded by SIX6 is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in eye development. Defects in this gene are a cause of isolated microphthalmia with cataract type 2 (MCOPCT2).