Rat Interleukin 10, IL-10 ELISA Kit, 96T Cell Senescence Multiple alternatively spliced transcript variants

Multiple alternatively spliced transcript variants have been identified in this gene

The encoded protein

high level in activated lymphocytes and monocytes

Mutation in one of the family members (bestrophin 1) is associated with vitelliform macular dystrophy

Required for the development of the anterior commissure in the brain by inhibiting neurite outgrowth (PubMed: 21055390

Rat Interleukin 10, IL-10 ELISA Kit, 96T Cell Senescence Multiple alternatively spliced transcript variantsMajor immune regulatory cytokine that acts on many cells of the immune system where it has profound anti inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2 mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti inflammatory mediators. Targets