IGFBP6 Polyclonal Antibody, 100ul Syringe Filter Alternatively spliced transcript variants encoding

Alternatively spliced transcript variants encoding different isoforms have also been described for this gene

May act as a protease inhibitor to modulate the host immune response against tumor cells

up-regulates transcription from the osteocalcin promoter

It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes

The encoded protein may regulate colonic smooth muscle contraction through binding to its cognate receptor

IGFBP6 Polyclonal Antibody, 100ul Syringe Filter Alternatively spliced transcript variants encodingIGF binding proteins prolong the half life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.