Presenilin 1 Polyclonal Antibody, 20ul Monoclonal Antibodies -2 and -3) are members

-2 and -3) are members of the serpin serine proteinase inhibitor family

The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase

and neurons

This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling

ZCCHC17 contains one CCHC-type zinc finger

Presenilin 1 Polyclonal Antibody, 20ul Monoclonal Antibodies -2 and -3) are membersAlzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease linked mutations result in increased production of the longer form of amyloid beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma secretase, an enzyme that cleaves APP.