PARP-1 Polyclonal Antibody, 20ul[BT-AP06934] Adeno-associated Virus Packaging An important paralog of this

An important paralog of this gene is NAA16

which contains 29 genes in the immunoglobulin superfamily

with dysregulation linked to cancer

This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation

Mutations in this gene are associated with nail-patella syndrome

PARP-1 Polyclonal Antibody, 20ul[BT-AP06934] Adeno-associated Virus Packaging An important paralog of thisPARP1 (poly(ADP ribose) polymerase 1) encodes a chromatin associated enzyme, poly(ADP ribosyl)transferase, which modifies various nuclear proteins by poly(ADP ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In