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INTS2 Polyclonal Antibody, 100ul Primary Antibodies The A-kinase anchor proteins (AKAPs)

SKU: 30418603867

4.7
EUR141.00 EUR165.00

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INTS2 Polyclonal Antibody, 100ul Primary Antibodies The A-kinase anchor proteins (AKAPs)INTS2 (integrator complex subunit 2) is a subunit of the Integrator complex, which associates with the C terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3 prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690).

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Description

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell

An important paralog of this gene is NCOA7

Interacts with p53 (TP53)

ADCA is caused by the expansion of the CAG repeats

suggesting that this serpin plays an important role in the inner ear in the protection against leakage of lysosomal content during stress

INTS2 Polyclonal Antibody, 100ul Primary Antibodies The A-kinase anchor proteins (AKAPs)INTS2 (integrator complex subunit 2) is a subunit of the Integrator complex, which associates with the C terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3 prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690).

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