p53 Polyclonal Antibody, 50ul[BT-AP06808] Antibody Development Binds preferrentially ferritin light chain

Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1)

The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression

Multiple alternatively spliced transcript variants encoding different isoforms have been identified in CD4

A short peptide derived from this protein is a minor histocompatibility antigen which can lead to graft rejection of male donor cells in a female recipient

the second at Ser-46

p53 Polyclonal Antibody, 50ul[BT-AP06808] Antibody Development Binds preferrentially ferritin light chainTP53 encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The tumor protein p53 responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li Fraumeni syndrome.