CILP1 Polyclonal Antibody, 20ul Centrifuges Dok-6 is highly expressed in

Dok-6 is highly expressed in the developing central nervous system

The protein encoded by this gene belongs to the leucine-rich repeat superfamily

which is required for p53-mediated transcription activation

A pseudogene is located on chromosome 11

These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD

CILP1 Polyclonal Antibody, 20ul Centrifuges Dok-6 is highly expressed inMajor alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. This gene encodes the cartilage intermediate layer protein (CILP), which increases in early osteoarthrosis cartilage. The encoded protein was thought to encode a protein precursor for two different proteins; an N terminal CILP and a C terminal homolog of NTPPHase, however, later studies identified no nucleotide pyrophosphatase