AIRE-1 Polyclonal Antibody, 50ul[BT-AP00312] DNA Oligo Synthesis Three alternatively spliced transcript variants

Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene

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The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation

Alternatively spliced transcript variants encoding different isoforms have been found in GABRA4

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AIRE-1 Polyclonal Antibody, 50ul[BT-AP00312] DNA Oligo Synthesis Three alternatively spliced transcript variantsAIRE encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein (autoimmune regulator) plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T cells in the thymus. Mutations in this gene cause the rare autosomal recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with