RN123 Polyclonal Antibody, 20ul Custom RNA Oligos The filaggrin-like protein encoded by

The filaggrin-like protein encoded by this gene is upregulated by calcium| proteolyzed by calpain 1| and is involved in epithelial homeostasis

This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals

A pseudogene of this gene is located on the short arm of chromosome 17

Acetylation disappears at mitosis

PAH encodes the enzyme phenylalanine hydroxylase that is the rate-limiting step in phenylalanine catabolism

RN123 Polyclonal Antibody, 20ul Custom RNA Oligos The filaggrin-like protein encoded byThe protein encoded by this gene contains a C terminal RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein protein and protein DNA interactions, and an N terminal SPRY domain. This protein displays E3 ubiquitin ligase activity toward the cyclin dependent kinase inhibitor 1B which is also known as p27 or KIP1. Alternative splicing results in multiple transcript variants.