Rat Mothers Against Decapentaplegic Homolog 2, SMAD2 ELISA Kit, 96T Mini dry bath This gene encodes a DENN

This gene encodes a DENN domain-containing protein that may function as a guanine nucleotide exchange factor that specifically activates ras-related protein Rab-10

There is a pseudogene for ALMS1 located adjacent in the same region of chromosome 2

Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd)

This protein may also be involved in promoting apoptosis

which is found in a gene cluster at chromosomal region 19q13

Rat Mothers Against Decapentaplegic Homolog 2, SMAD2 ELISA Kit, 96T Mini dry bath This gene encodes a DENNReceptor regulated SMAD (R SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF beta and, on formation of the SMAD2 SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by