Vav1(Phospho Tyr174) Polyclonal Antibody, 100ul Reagent Reservoirs bone marrow and peripheral blood

bone marrow and peripheral blood leukocytes

Involved in tolerance to glucose starvation

Quality control in the endoplasmic reticulum (ER) ensures that only properly folded proteins are retained in the cell through recognition and degradation of misfolded or unassembled proteins

slow- and cardiac-type isoforms

Mutations in this gene cause pseudoxanthoma elasticum

Vav1(Phospho Tyr174) Polyclonal Antibody, 100ul Reagent Reservoirs bone marrow and peripheral bloodThis gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T cell and B cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV 1.