RUBIC Rabbit Polyclonal Antibody, 20ul Immunology The protein (BCL2 like 1)

The protein (BCL2 like 1) encoded by BCL2L1belongs to the BCL-2 protein family

and are involved in a variety of biological processes including embryonic development cell growth

The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor

The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal

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RUBIC Rabbit Polyclonal Antibody, 20ul Immunology The protein (BCL2 like 1)The protein encoded by this gene is a negative regulator of autophagy and endocytic trafficking and controls endosome maturation. This protein contains two conserved domains an N terminal RUN domain and a C terminal DUF4206 domain. The RUN domain is involved in Ras like GTPase signaling and the DUF4206 domain contains a diacylglycerol (DAG) binding like motif. Mutation in this gene results in deletion of the DAG binding like motif and causes a