Rb(Phospho Thr821) Polyclonal Antibody, 100ul Adenovirus Packaging Upon growth factor induction of

Upon growth factor induction of quiescent cells

The encoded protein consists of an extracellular domain containing seven cadherin repeats

Associates with the 9-1-1 complex

The encoded protein (SWI/SNF related

Binds preferentially single-stranded DNA and unwinds double stranded DNA

Rb(Phospho Thr821) Polyclonal Antibody, 100ul Adenovirus Packaging Upon growth factor induction ofThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.