Mouse DNA Topoisomerase 1, TOP1 ELISA Kit, 96T Enzymes Contains 1 EGF-like domain

Contains 1 EGF-like domain

subcellular location:Colocalizes with a lysosomal protein cathepsin D

Binds to a consensus sequence in gene promoters (By similarity)

Alternative splicing or deletion caused by a translocation event in this paternally-expressed region is responsible for Angelman syndrome or Prader-Willi syndrome due to parental imprint switch failure

This gene is highly expressed in the brain and may function as an integrin ligand in the brain

Mouse DNA Topoisomerase 1, TOP1 ELISA Kit, 96T Enzymes Contains 1 EGF-like domainReleases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA (3' phosphotyrosyl) enzyme intermediate and the expulsion of a 5' OH