Rb(Phospho Ser608) Polyclonal Antibody, 100ul Protein Analysis Apoptosis antagonizing transcription factor encoded

Apoptosis antagonizing transcription factor encoded by AATF was identified on the basis of its interaction with MAP3K12/DLK

Alternative splicing results in several transcript variants encoding different isoforms

Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene

The acidic C-terminal region of the encoded protein can act as a transactivation domain

Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes

Rb(Phospho Ser608) Polyclonal Antibody, 100ul Protein Analysis Apoptosis antagonizing transcription factor encodedThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.