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PKR(Phospho Thr258) Polyclonal Antibody, 50ul Cell fragmentation and collection Acting as a GTPase activating

SKU: 16733840037

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PKR(Phospho Thr258) Polyclonal Antibody, 50ul Cell fragmentation and collection Acting as a GTPase activatingThe protein encoded by this gene is a serine threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene.

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Description

Acting as a GTPase activating protein (GAP)

IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al

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It also interacts with multiple intracellular calcium release channels| and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor

This gene encodes a membrane-bound protein that is a member of the mucin family

PKR(Phospho Thr258) Polyclonal Antibody, 50ul Cell fragmentation and collection Acting as a GTPase activatingThe protein encoded by this gene is a serine threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene.

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