PEK/PERK Polyclonal Antibody, 100ul Organelle Studies CLIC6 is part of a

CLIC6 is part of a large triplicated region found on chromosomes 1

The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia

Belongs to the MMR1/HSR1 GTP-binding protein family

The protein encoded by this gene is a nuclear encoded endonuclease that is localized in the mitochondrion

The auxiliary subunits function in the assembly and membrane localization of the complex

PEK/PERK Polyclonal Antibody, 100ul Organelle Studies CLIC6 is part of aThe protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in