Nur77(Phospho Ser351) Polyclonal Antibody, 20ul NGS Oligos SHC1 encodes three main isoforms

SHC1 encodes three main isoforms that differ in activities and subcellular location

Phosphorylation of Tyr-358 is involved in binding to PTPN6

The protein encoded by this gene contains a GTPase-activating protein domain

with the accessory tools provided

tissue specificity:Monocytic/myeloid lineage cells

Nur77(Phospho Ser351) Polyclonal Antibody, 20ul NGS Oligos SHC1 encodes three main isoformsThis gene encodes a member of the steroid thyroid hormone retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.