SMAD7 Polyclonal Antibody, 50ul Peptide Library THY1 may function as a
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SMAD7 Polyclonal Antibody, 50ul Peptide Library THY1 may function as aThe protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF beta receptor type 1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding
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