Presenilin 1 Polyclonal Antibody, 50ul Biomatrix The importance of angiotension II

The importance of angiotension II

By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain

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This protein may also function as a tumor suppressor in some cancers

The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs

Presenilin 1 Polyclonal Antibody, 50ul Biomatrix The importance of angiotension IIAlzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease linked mutations result in increased production of the longer form of amyloid beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma secretase, an enzyme that cleaves APP.