CHIP Polyclonal Antibody, 20ul In vitro Transcription may play a key role

may play a key role in cell cycle progression and tumorigenesis

Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed: 20074560)

Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines

take charge and reach new heights

and cell proliferation

CHIP Polyclonal Antibody, 20ul In vitro Transcription may play a key roleThis gene encodes a protein containing tetratricopeptide repeat and a U box that functions as a ubiquitin ligase cochaperone. The encoded protein binds to and ubiquitinates shock cognate 71 kDa protein (Hspa8) and DNA polymerase beta (Polb), among other targets. Mutations in this gene cause spinocerebellar ataxia, autosomal recessive 16. Alternative splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 2.