Rb(Phospho Ser249) Polyclonal Antibody, 100ul ROS/Nitric Oxide Detection BNIP1/SEC20L

BNIP1/SEC20L

The RefSeq Project has decided to create four representative RefSeq records

The protein encoded by this gene consists of two polypeptide chains activated from a single precursor protein by proteolysis

and is thus a member of the WFDC domain family

PRKACG is intronless and is thought to be a retrotransposon derived from the gene for the alpha form of the PKA catalytic subunit

Rb(Phospho Ser249) Polyclonal Antibody, 100ul ROS/Nitric Oxide Detection BNIP1/SEC20LThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.