PYK2(Phospho Tyr402) Polyclonal Antibody, 100ul RNA Tools This protein is activated through

This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs| EGF| IL5| IL6| HGF| LIF and BMP2

Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene

Alternative splicing of CDC14A results in several transcript variants encoding distinct isoforms

The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP

The exact function of this gene is not known but studies in rat suggest a role in cellular proliferation and c-Myc-mediated transformation

PYK2(Phospho Tyr402) Polyclonal Antibody, 100ul RNA Tools This protein is activated throughThis gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and