PA26 Polyclonal Antibody, 20ul Cellular Cultivation & Health Management Mutations in this gene are

Mutations in this gene are associated with nail-patella syndrome

The C-terminal helical region containing domains I and II are separated by domain alpha

2008 [PubMed 18209477])

Mutations in TP53 are associated with a variety of human cancers

This family member is localized to 11q12

PA26 Polyclonal Antibody, 20ul Cellular Cultivation & Health Management Mutations in this gene areSESN1 encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The sestrin 1 mediates p53 inhibition of cell growth by activating AMP activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized