Raf-1 Polyclonal Antibody, 100ul[BT-AP13533] Polyclonal Antibodies These variants encode different isoforms|

These variants encode different isoforms| which are differentially expressed and have different kinase activities

The growth factor receptor bound protein 2 encoded by GRB2 binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit

This domain is found in proteins encoded by the TCEAL elongation factor (transcription elongation factor A (SII)-like) gene family also located on the X chromosome

This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis

Raf-1 Polyclonal Antibody, 100ul[BT-AP13533] Polyclonal Antibodies These variants encode different isoforms|This gene is the cellular homolog of viral raf gene (v raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine threonine specific protein kinases, ERK1 and ERK2.