SNPH Polyclonal Antibody, 20ul Antibody Humanization Mutations in this gene are

Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR)

Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits| large and small| that dimerize to form the active enzyme

Several pseudogenes have been reported for this gene

and multiple structural subunits encoded by nuclear genes

PIK3R1 and SH3KBP1/CIN85

SNPH Polyclonal Antibody, 20ul Antibody Humanization Mutations in this gene areSyntaxin 1, synaptobrevin VAMP, and SNAP25 interact to form the SNARE complex, which is required for synaptic vesicle docking and fusion. The protein encoded by this gene is membrane associated and inhibits SNARE complex formation by binding free syntaxin 1. Expression of this gene appears to be brain specific. Alternative splicing results in multiple transcript variants encoding different isoforms.