HSP27 Monoclonal Antibody, 100ul Culture Tubes The protein encoded by this

The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions

It contains a 5' CpG island that may be a frequent target of hypermethylation| and it may undergo hypermethylation-based silencing in some bladder cancers

The two proteins share 50% sequence identity in this repeat-containing region

resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production

A pseudogene of this gene is found on chromosome 5

HSP27 Monoclonal Antibody, 100ul Culture Tubes The protein encoded by thisThe protein encoded by this gene is induced by environmental stress and developmental changes. The encoded protein is involved in stress resistance and actin organization and translocates from the cytoplasm to the nucleus upon stress induction. Defects in this gene are a cause of Charcot Marie Tooth disease type 2F (CMT2F) and distal hereditary motor neuropathy (dHMN).